Prostate cancer metastasis linked to revival of dormant molecular program


21-07-2020
Data confirm decades-old hypothesis that metastatic disease hijacks tissue-specific developmental programs.
 
When prostate cancer progresses to a more-dangerous metastatic state, it does so by resurrecting dormant molecular mechanisms that had guided the fetal development of the prostate gland but had been subsequently switched off, say scientists from Dana-Farber Cancer Institute. The study, an international collaboration with The Netherlands Cancer Institute, was published ...